is the only sceletium tortuosum extract with published pharmacology. It is produced from an elite, naturally occurring chemo-type of sceletium tortuosum plant clinically studied for safety. Zembrin® is the only sceletium tortuosum formulation with a permit for full compliance under the Biodiversity Act. This first ever export permit from the South African Government enables it to carry the logos of its indigenous beneficiaries - The South African San Council. Accept no sceletium tortuosum substitutesRecent Post
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Benefits
- Backed by over 300 years of documented indigenous use
- Non-habit forming, well tolerated
Zembrin® / Sceletium Tortuosum Overview:
“…it is the greatest restorative and cheerer of the soul…” – Kolbe, 1705
Based on 12 years of Research & Development, Zembrin® Sceletium Tortuosum is distinguished from cruder forms of the herb due to its richness in mesembrenone and mitigation of mesembrine. Most people are aware of the concept of selective serotonin re-uptake inhibition (SSRI). For those of you who are not this means that it blocks the re-absorption (re-uptake) of the neurotransmitter serotonin, forcing it out into the synaptic cleft. By shifting the balance of serotonin brain cells are more easily able to send and receive chemical messages, which in turn boosts mood. But sceletium tortuosum does more than act as an SSRI. Sceletium is also a PDE4 enzyme inhibitor. Certain enzymes constrict blood flow in the brain. The PDE4 enzyme inhibitor allows for easier vasodilation and blood flow which increases oxygen flow in the brain and body much like the male erectile dysfunction drug Viagra which is a PDE5 enzyme inhibitor. (Opium is a PDE10 enzyme inhibitor). Hence, the high serotonin re-uptake release combined with PDE4 inhibition allows one to experience a nice combination of stimulation and relaxation. Please understand that unlike opium Sceletium is 100% safe and non-addictive. The Zembrin® patent reflects that it has been very carefully standardized for total alkaloid content produced from an in-house selection of plants with the most desirable mix of actives. It’s safety is further defined by a GC-MS chromatographic profile for its 4 key alkaloids. This has been supported by Ames, Micronucleus, hERG, MTD Acute Toxicity, 90 day Sub-chronic toxicity, & Phase 1 Safety Study with 37 subjects). To be sure, Sceletium Tortuosum does not produce any major side effects, but some individuals do experience profound relaxation, hence it should not be taken before operating any type of machinery. Zembrin® should not be taken in conjunction with any other psychoactive substance or by pregnant or nursing women except under the supervision of their primary health practitioner.
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The Study Process
Sceletium Tortuosum contains Mesembrine, which is a potent serotonin-uptake inhibitor with a novel mechanism of action for this known molecule, that suggests therapeutic applications for anxiety, d
Pharmacological Properties
Sceletium Tortuosum contains Mesembrine, which is a potent serotonin-uptake inhibitor with a novel mechanism of action for this known molecule, that suggests therapeutic applications for anxiety, d...
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Affiliation
Unique selection of the South African plant Sceletium that is rich in mesembrenone, and low in mesembrine developed into a proprietary, standardized extract, trade
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