Scletium Tortuosum has been show to help reduce stress in its users over time.
Based on 12 years of Research & Development, Zembrin® Sceletium Tortuosum is distinguished from cruder forms of the herb due to its richness in mesembrenone and mitigation of mesembrine. Most people are aware of the concept of selective serotonin re-uptake inhibition (SSRI). For those of you who are not this means that it blocks the re-absorption (re-uptake) of the neurotransmitter serotonin, forcing it out into the synaptic cleft. By shifting the balance of serotonin brain cells are more easily able to send and receive chemical messages, which in turn boosts mood.
Sceletium Tortuosum does more than act as an SSRI. Sceletium is also a PDE4 enzyme inhibitor. Certain enzymes constrict blood flow in the brain. The PDE4 enzyme inhibitor allows for easier vasodilation and blood flow which increases oxygen flow in the brain and body much like the male erectile dysfunction drug Viagra which is a PDE5 enzyme inhibitor. (Opium is a PDE10 enzyme inhibitor). Hence, the high serotonin re-uptake release combined with PDE4 inhibition allows one to experience a nice combination of stimulation and relaxation.
Sceletium is 100% safe and non-addictive. The Zembrin® patent reflects that it has been very carefully standardized for total alkaloid content produced from an in-house selection of plants with the most desirable mix of actives. It’s safety is further defined by a GC-MS chromatographic profile for its 4 key alkaloids. This has been supported by Ames, Micronucleus, hERG, MTD Acute Toxicity, 90 day Sub-chronic toxicity, & Phase 1 Safety Study with 37 subjects).
NO MAJOR SIDE EFFECTS
Sceletium Tortuosum does not produce any major side effects, but some individuals do experience profound relaxation, hence it should not be taken before operating any type of machinery. Zembrin® should not be taken in conjunction with any other psychoactive substance or by pregnant or nursing women except under the supervision of their primary health practitioner.